S1PR₄ deficiency results in reduced germinal center formation but only marginally affects antibody production.

ABSTRACT:

Introduction

Splenic B cells exhibit a high expression of the G protein-coupled sphingosine-1-phosphate (S1P) receptor type 4 (S1PR₄). Little is known about the functional relevance of S1PR₄ expression on those cells.

Methods

In this study, S1PR₄-deficient mice were used to study the role of S1PR₄-mediated S1P signaling in B cell motility in vitro and for the maintenance of the splenic architecture under steady state conditions as well as in polymicrobial abdominal sepsis in vivo. Finally, the impact of S1PR₄ deficiency on antibody production after immunization with T cell dependent antigens was assessed.

Results

Loss of S1PR₄ resulted in minor alterations of the splenic architecture conce

SUBMITTER: Riese J 

PROVIDER: S-EPMC9755867 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature