CD45RO+TILs: cellular biomarkers for larynx squamous cell carcinoma outcome.

ABSTRACT:

Objective

The prognostic importance of Tumor-Infiltrating Lymphocytes (TILs) in the tumor microenvironment of various cancers is increasingly recognized. In the present study, we aimed to investigate the prognostic value of CD3+, CD4+, CD8+, and CD45RO + TILs and their relation to histopathological features in larynx squamous cell carcinoma.

Methods

Formalin-Fixed and Paraffin-Embedded (FFPE) samples from 63 primary larynx squamous cell carcinoma patients were immunostained for CD3, CD4, CD8, and CD45RO expression. Positive cells in micrographs from Invasive Margin (IM) and Tumor Center (CT) of tissue specimens counted by ImageJ software and their correlation with disease outcome were analyzed.

Results

The expression level of TILs subpopulations was associated with cl

SUBMITTER: Mohammadi Y 

PROVIDER: S-EPMC9756076 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature