Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase.

ABSTRACT: Maintaining an appropriate balance between excitation and inhibition is critical for neuronal information processing. Cortical neurons can cell-autonomously adjust the inhibition they receive to individual levels of excitatory input, but the underlying mechanisms are unclear. We describe that Ste20-like kinase (SLK) mediates cell-autonomous regulation of excitation-inhibition balance in the thalamocortical feedforward circuit, but not in the feedback circuit. This effect is due to regulation of inhibition originating from parvalbumin-expressing interneurons, while inhibition via somatostatin-expressing interneurons is unaffected. Computational modeling shows that this mechanism promotes stable excitatory-inhibitory ratios across pyramidal cells and ensures robust and sparse coding. Patch-c

SUBMITTER: Royero P 

PROVIDER: S-EPMC9756112 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature