Tumor immune microenvironment in endometrial cancer of different molecular subtypes: evidence from a retrospective observational study.

ABSTRACT:

Objective

Tumor immune microenvironmental features may predict survival and guide treatment. This study aimed to comprehensively decipher the immunological features of different molecular subtypes of endometrial cancer.

Methods

In this retrospective study, 26 patients with primary endometrial cancer and four with recurrent disease treated in our center from December 2018 to November 2021 were included. Next-generation sequencing was performed on tumor samples. Patients were classified into four subtypes, including POLE mutant, microsatellite instability high (MSI-H), no specific molecular profile (NSMP) and TP53 mutant subtypes. Tumor-infiltrating immune cells were quantified using multiplex immunofluorescence assays.

Results

Of the 26 primary endometria

SUBMITTER: Dai Y 

PROVIDER: S-EPMC9756131 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature