Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress.

ABSTRACT:

Background

Metabolic disorder is considered a well-established risk factor for endometrial carcinoma (EC). However, the mechanism remains unclear. Insulin resistance and excessive flux of free fatty acids serve as fundamental pathogenic factors in metabolic disorders, including obesity and type 2 diabetes. The aim of this study was to test the correlation between insulin resistance and dyslipidaemia in EC and to determine the effect of insulin and saturated fatty acids on EC cells.

Methods

A retrospective study on the medical records of patients with EC and RNA-seq from the TCGA database analysed with edgR and Gene Ontology (GO) were used to assess the correlation of dyslipidaemia and diabetes as well as obesity. Crystal violet assays and CCK-8 assays were used to detect the

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9756454 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature