Association of CYP19A1 rs28757157 polymorphism with lung cancer risk in the Chinese Han population.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer death globally. Recent studies have revealed that CYP19A1 gene plays a crucial role in cancer initiation and development. The aim of this study was to assess the association of CYP19A1 genetic polymorphisms with the risk of lung cancer in the Chinese Han population.

Methods

This study randomly recruited 489 lung cancer patients and 467 healthy controls. The genotypes of four single nucleotide polymorphisms (SNPs) of the CYP19A1 gene were identified by the Agena MassARRY technique. Genetic model analysis was used to assess the association between genetic variations and lung cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the effect of four selected SNPs on lung cancer risk.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9756459 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature