Clinical characteristics of central nervous system candidiasis due to Candida albicans in children: a single-center experience.

ABSTRACT:

Background

Central nervous system candidiasis due to Candida albicans (CNSC) in children is easily misdiagnosed and is associated with poor outcomes and a high mortality rate. There is no big data research or systematic review of CNSC.

Methods

Patients diagnosed as CNSC with positive culture results of Candida albicans in Beijing Children's Hospital affiliated to Capital Medical University from March 2010 to March 2019 were included. Patients receiving immunosuppressive therapy or transplantation, or with malignant tumours were excluded. We analysed the clinical characteristics, follow-up results, drug susceptibility tests and whole-exome sequencing (WES) results.

Results

Thirty-three definitive patients were enrolled, including 22 males and 11 females. Twenty-five pa

SUBMITTER: Xiao H 

PROVIDER: S-EPMC9756474 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature