Multi-omic interactions in the gut of children at the onset of islet autoimmunity.

ABSTRACT:

Background

The gastrointestinal ecosystem is a highly complex environment with a profound influence on human health. Inflammation in the gut, linked to an altered gut microbiome, has been associated with the development of multiple human conditions including type 1 diabetes (T1D). Viruses infecting the gastrointestinal tract, especially enteroviruses, are also thought to play an important role in T1D pathogenesis possibly via overlapping mechanisms. However, it is not known whether the microbiome and virome act together or which risk factor may be of greater importance at the time when islet autoimmunity is initiated.

Results

Here, we apply an integrative approach to combine comprehensive fecal virome, microbiome, and metaproteome data sampled before and at the onset of isle

SUBMITTER: Gavin PG 

PROVIDER: S-EPMC9756488 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature