A cervical cancer biorepository for pharmacogenomics research in Zimbabwe.

ABSTRACT:

Background

Research infrastructures such as biorepositories are essential to facilitate genomics and its growing applications in health research and translational medicine in Africa. Using a cervical cancer cohort, this study describes the establishment of a biorepository consisting of biospecimens and matched phenotype data for use in genomic association analysis and pharmacogenomics research.

Method

Women aged > 18 years with a recent histologically confirmed cervical cancer diagnosis were recruited. A workflow pipeline was developed to collect, store, and analyse biospecimens comprising donor recruitment and informed consent, followed by data and biospecimen collection, nucleic acid extraction, storage of genomic DNA, genetic characterization, data integration, data analy

SUBMITTER: Kuguyo O 

PROVIDER: S-EPMC9756582 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature