Identification of serum MiRNAs as candidate biomarkers for non-small cell lung cancer diagnosis.

ABSTRACT:

Background

Lung cancer is one of the most common solid tumors worldwide and the leading cause of cancer-associated death. Non-small cell lung cancer (NSCLC) is accounts for approximately 85% of all the lung cancers and lung squamous carcinoma (SCC) and adenocarcinoma (ADC) are the main subtypes of NSCLC. Early diagnose using serum biomarkers could improve the overall survival of patients. In this study, we aimed to identify miRNAs from serum with clinical utility in the diagnosis of NSCLC.

Methods

Ten patients with SCC, ten patients with ADC and five noncancerous individuals were enrolled in the screening cohort. miRNA expression levels in serum were measured by microarray analysis. Candidate miRNAs were validated by real-time quantitative polymerase chain reaction analysis

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9756610 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature