Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.

ABSTRACT:

Introduction

Age is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. Circular RNAs (circRNAs) have been reported in many cognitive disorders, but their role in aging-related memory impairment is unclear.Methods: In this study, we aimed to investigate the effects of circ-Vps41 on aging-related hippocampus-dependent memory impairment and explore the potential mechanisms. Here, D-galactose was used to produce a conventional aging model resulting in memory dysfunction.

Results

Circ-Vps41 was significantly downregulated in D-galactose-induced aging in vitro and in v

SUBMITTER: Li Y 

PROVIDER: S-EPMC9756809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature