Ontology highlight
ABSTRACT:
SUBMITTER: Van Houten B
PROVIDER: S-EPMC9756857 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Van Houten Bennett B Schnable Brittani B Kumar Namrata N
BioEssays : news and reviews in molecular, cellular and developmental biology 20210223 5
We highlight a recent study exploring the hand-off of UV damage to several key nucleotide excision repair (NER) proteins in the cascade: UV-DDB, XPC and TFIIH. The delicate dance of DNA repair proteins is choreographed by the dynamic hand-off of DNA damage from one recognition complex to another damage verification protein or set of proteins. These DNA transactions on chromatin are strictly chaperoned by post-translational modifications (PTM). This new study examines the role that ubiquitylation ...[more]