Association of polymorphisms in the IL-10 promoter region with Crohn's disease.

ABSTRACT:

Background

IL-10 is thought to play an important role in preventing inflammatory bowel disease (IBD), although its efficacy is limited in IBD inflammation treatment. The purpose of this study is to investigate the association between SNP polymorphism in the promoter region of the IL-10 gene and Crohn's disease (CD).

Methods

In 86 children with CD disease and 142 healthy controls, polymorphisms of three SNPs (rs3790622, rs1800872, and rs1800896) in the IL-10 promoter region were successfully identified. The risk alleles, genotypes, and haplotypes were also analyzed in the CD patient group and the control group. 2 × 2 chi-square test was used to identify whether there is a statistically significant association between CD risk and SNP polymorphisms.

Results

According to

SUBMITTER: Sun A 

PROVIDER: S-EPMC9757008 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature