Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation.

ABSTRACT: Molecular alterations as a result of exposure to low doses of high linear energy transfer (LET) radiation can have deleterious short- and long-term consequences on crew members embarking on long distance space missions. Oxygen ions (¹⁶O) are among the high LET charged particles that make up the radiation environment inside a vehicle in deep space. We used mass spectrometry-based metabolomics to characterize urinary metabolic profiles of male C57BL/6J mice exposed to a single dose of 0.1, 0.25 and 1.0 Gy of ¹⁶O (600 MeV/n) at 10 and 30 days post-exposure to delineate radiation-induced metabolic alterations. We recognized a significant down regulation of several classes of metabolites including cresols and tryptophan metabolites, ketoacids and their derivatives upon exp

SUBMITTER: Girgis M 

PROVIDER: S-EPMC9757021 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature