Disease Burden Affects Aging Brain Function.

ABSTRACT:

Background

Most older adults live with multiple chronic disease conditions, yet the effect of multiple diseases on brain function remains unclear.

Methods

We examine the relationship between disease multimorbidity and brain activity using regional cerebral blood flow (rCBF) 15O-water PET scans from 97 cognitively normal participants (mean baseline age 76.5) in the Baltimore Longitudinal Study of Aging (BLSA). Multimorbidity index scores, generated from the presence of 13 health conditions, were correlated with PET data at baseline and in longitudinal change (n = 74) over 5.05 (2.74 SD) years.

Results

At baseline, voxel-based analysis showed that higher multimorbidity scores were associated with lower relative activity in orbitofrontal, superior frontal, temporal pole

SUBMITTER: Beason-Held LL 

PROVIDER: S-EPMC9757056 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature