Average saturation efficiency filter ASEF-CEST MRI of stroke rodents.

ABSTRACT:

Purpose

The average saturation efficiency filter (ASEF) is a novel method of improving the specificity of CEST; however, there is a mismatch between the magnetization transfer (MT) effect under high-duty cycle and low-duty cycle pulse trains. We explore measures of mitigation and the sensitivity and potential of ASEF imaging in phantoms and stroke rats.

Methods

Simulation and nicotinamide phantoms in denatured protein were used to investigate the effect of different average saturation powers and MT pool parameters on matching coefficients used for correction as well as the ASEF ratio signal and baseline. Then, in vivo studies were performed in stroke rodents to further investigate the sensitivity and fidelity of ASEF ratio spectra.

Results

Simulation and studies of ni

SUBMITTER: Chung JJ 

PROVIDER: S-EPMC9757140 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature