Clinical and laboratory characterization of adult sickle cell anemia patients in Kinshasa.

ABSTRACT:

Background

Sickle cell anemia (SCA) is a monogenic hemoglobinopathy associated with severe acute and chronic complications, with the highest incidence worldwide in Sub-Saharan Africa. The wide variability in clinical manifestations suggest that a uniform response to hydroxurea may not be attained. In view of a potential treatment with hydroxyurea (HU), we assessed the variability of clinical and hematological manifestations in a cohort of adults with SCA in Kinshasa, capital of the DR Congo in Central Africa.

Methods

A cross-sectional study was conducted in a hospital dedicated to SCA management in Kinshasa. Clinical history of patients was recorded, a complete physical examination performed. The diagnosis was confirmed by means of DNA analysis. A full blood count and hemoly

SUBMITTER: Lumbala PK 

PROVIDER: S-EPMC9757547 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature