Power analysis for idiographic (within-subject) clinical trials: Implications for treatments of rare conditions and precision medicine.

ABSTRACT: Power analysis informs a priori planning of behavioral and medical research, including for randomized clinical trials that are nomothetic (i.e., studies designed to infer results to the general population based on interindividual variabilities). Far fewer investigations and resources are available for power analysis of clinical trials that follow an idiographic approach, which emphasizes intraindividual variabilities between baseline (control) phase versus one or more treatment phases. We tested the impact on statistical power to detect treatment outcomes of four idiographic trial design factors that are under researchers' control, assuming a multiple baseline design: sample size, number of observations per participant, proportion of observations in the baseline phase, and competing statis

SUBMITTER: Tueller S 

PROVIDER: S-EPMC9757638 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature