Detection of intracellular lamellar bodies as a screening marker for fibrotic lesions.

ABSTRACT: With the rapid increase in application of disinfectants worldwide as a method to block the spread of coronavirus, many new products are being introduced into the market without thorough verification of their impacts on human health and the environment. In the present study, we aimed to propose a screening marker for materials that can induce fibrotic lung disease using disinfectants, which had been demonstrated as causative materials of chronic inflammation and interstitial fibrosis. We first calculated the corresponding LC₅₀ level based on results from cell viability test and exposed the LC₅₀ level of disinfectants to human bronchial epithelial cells for 24 h. Formation of lamellar body-like structures, cleavage of the nuclear matrix, structural damage of mitochondri

SUBMITTER: Park EJ 

PROVIDER: S-EPMC9757665 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature