Utility of Multimodality Approach Including Systemic FGF23 Venous Sampling in Localizing Phosphaturic Mesenchymal Tumors.

ABSTRACT:

Context

Tumor-induced osteomalacia (TIO) is one of the most common forms of acquired fibroblast growth factor 23 (FGF23)-related hypophosphatemia and is usually caused by phosphaturic mesenchymal tumors (PMTs). Although the complete resection of PMTs can cure TIO, preoperative localization of tumors by standard imaging modalities is often challenging. In addition to ¹⁸F-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography (FDG-PET) and ¹¹¹In-pentetreotide scintigraphy (SRS), systemic FGF23 venous sampling (FGF23VS) has been used to help localize PMTs in specialized institutions.

Objective

This study aimed to evaluate the diagnostic performance of each imaging test and their combinations in localizing PMTs.

Methods

In an obser

SUBMITTER: Kato H 

PROVIDER: S-EPMC9757682 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature