Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study.

ABSTRACT:

Background

Over a life course, human adaptive immunity to antigenically mutable pathogens exhibits competitive and facilitative interactions. We hypothesize that such interactions may lead to cyclic dynamics in immune responses over a lifetime.

Methods

To investigate the cyclic behavior, we analyzed hemagglutination inhibition titers against 21 historical influenza A(H3N2) strains spanning 47 years from a cohort in Guangzhou, China, and applied Fourier spectrum analysis. To investigate possible biological mechanisms, we simulated individual antibody profiles encompassing known feedbacks and interactions due to generally recognized immunological mechanisms.

Results

We demonstrated a long-term periodicity (about 24 years) in individual antibody responses. The reported c

SUBMITTER: Yang B 

PROVIDER: S-EPMC9757834 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature