Cortisol awakening response and developmental outcomes at 6-7 years in children born extremely preterm.

ABSTRACT:

Background

Extremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children.

Methods

This secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed.

Results

Cortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-I

SUBMITTER: Lowe J 

PROVIDER: S-EPMC9758271 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature