COVID-19 is not a causal risk for miscarriage: evidence from a Mendelian randomization study.

ABSTRACT:

Objective

Coronavirus disease 2019 (COVID-19) has caused a global pandemic in the last three years. The lack of reliable evidence on the risk of miscarriage due to COVID-19 has become a concern for patients and obstetricians. We sought to identify rigorous evidence using two-sample Mendelian randomization (MR) analysis.

Methods

Seven single-nucleotide polymorphisms (SNPs) associated with COVID-19 were used as instrumental variables to explore causality by two-sample MR. The summary data of genetic variants were obtained from the Genome Wide Association Study (GWAS) among European populations in the UK Biobank and EBI database. Inverse variance weighting (IVW) method was taken as the gold standard for MR results, and other methods were taken as auxiliary. We also performed se

SUBMITTER: Shi H 

PROVIDER: S-EPMC9758471 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature