Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.

ABSTRACT: Mitochondrial dysfunction causes the production of reactive oxygen species (ROS) and oxidative damage, and oxidative stress and inflammation are considered key factors causing intervertebral disc degeneration (IVDD). Thus, restoring the mitochondrial dysfunction is an attractive strategy for treating IVDD. Platelet-derived extracellular vesicles (PEVs) are nanoparticles that target inflammation. Moreover, the vesicles produced by platelets (PLTs) have considerable anti-inflammatory effects. We investigate the use of PEVs as a therapeutic strategy for IVDD in this study. We extract PEVs and evaluate their properties; test their effects on H₂O₂-induced oxidative damage of nucleus pulposus (NP) cells; verify the role of PEVs in repairing H₂O₂-induce

SUBMITTER: Dai Z 

PROVIDER: S-EPMC9758573 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature