Association of tumor immune microenvironment profiling and 21-gene recurrence assay in early breast cancer patients.

ABSTRACT:

Introduction

Tumor immune microenvironment (TIME) plays a vital role in breast cancer development, treatment resistance, and prognosis. This study evaluates the association of TIME profiling and 21-gene recurrence score (RS) in early Luminal breast cancer patients.

Methods

ER+ /HER2-, pN0 breast cancer patients with available RS results who received surgery between January 2009 and December 2013 were enrolled. TIME markers, including stromal tumor infiltrating lymphocytes (TILs), CD3, CD4, CD8, and tumor PD-L1 expression, were comprehensively analyzed. Association of TIME markers with RS, as well as their correlation with breast cancer-specific survival (BCSS) were tested.

Results

Overall, 385 patients were included, of whom 341 (88.6%) had TILs ≤10%. TIME markers wer

SUBMITTER: Tong Y 

PROVIDER: S-EPMC9758791 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature