Spatial-temporal regulation of fatty alcohol biosynthesis in yeast.

ABSTRACT:

Background

Construction of efficient microbial cell factories is one of the core steps for establishing green bio-manufacturing processes. However, the complex metabolic regulation makes it challenging in driving the metabolic flux toward the product biosynthesis. Dynamically coupling the biosynthetic pathways with the cellular metabolism at spatial-temporal manner should be helpful for improving the production with alleviating the cellular stresses.

Results

In this study, we observed the mismatch between fatty alcohol biosynthesis and cellular metabolism, which compromised the fatty alcohol production in Saccharomyces cerevisiae. To enhance the fatty alcohol production, we spatial-temporally regulated fatty alcohol biosynthetic pathway by peroxisomal compartmentalization (s

SUBMITTER: Gao N 

PROVIDER: S-EPMC9758912 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature