Effect of proton pump inhibitors in infants with esophageal atresia on the gut microbiome: a pilot cohort.

ABSTRACT:

Background

The effects of proton-pump inhibitors (PPIs) on the infant microbiome remain unclear. Swedish pilot cohort study to assess the longitudinal effect of long-term PPI on the infant gut microbiome, including ten newborn infants operated for esophageal atresia exposed to PPIs (mean 57 weeks), compared to healthy one-year-old controls. All children were born vaginally and were otherwise healthy. Within- and between sample diversity of the fecal microbiome was assessed using untargeted whole genome Shotgun metagenomics which sequences all the DNA in the sample and can capture genes rather than a taxonomic fingerprint.

Results

A longer duration of PPI-use was associated with considerable changes in evenness and high variation on diversity within samples compared to a shor

SUBMITTER: Brusselaers N 

PROVIDER: S-EPMC9758939 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature