Cell senescence-associated genes predict the malignant characteristics of glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is the most malignant, aggressive and recurrent primary brain tumor. Cell senescence can cause irreversible cessation of cell division in normally proliferating cells. According to studies, senescence is a primary anti-tumor mechanism that may be seen in a variety of tumor types. It halts the growth and spread of tumors. Tumor suppressive functions held by cellular senescence provide new directions and pathways to promote cancer therapy.

Methods

We comprehensively analyzed the cell senescence-associated genes expression patterns. The potential molecular subtypes were acquired based on unsupervised cluster analysis. The tumor immune microenvironment (TME) variations, immune cell infiltration, and stemness index between 3 subtypes were analyzed. T

SUBMITTER: Tan C 

PROVIDER: S-EPMC9758946 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature