Identification of multi-targeting natural antiviral peptides to impede SARS-CoV-2 infection.

ABSTRACT: SARS-CoV-2 and its variants cause serious health concerns throughout the world. The alarming increase in the daily number of cases has become a nightmare in many low-income countries; although some vaccines are available, their high cost and low vaccine production make them unreachable to ordinary people in developing countries. Other treatment strategies are required for novel therapeutic options. The peptide-based drug is one of the alternatives with low toxicity, more specificity, and ease of synthesis. Herein, we have applied structure-based virtual screening to identify potential peptides targeting the critical proteins of SARS-CoV-2. Non-toxic natural antiviral peptides were selected from the enormous number of peptides. Comparative modeling was applied to prepare a 3D structure of s

SUBMITTER: Singh S 

PROVIDER: S-EPMC9759041 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature