Maternal glycaemic and insulinemic status and newborn DNA methylation: findings in women with overweight and obesity.

ABSTRACT:

Context

Maternal dysglycaemia and pre-pregnancy obesity are associated with adverse offspring outcomes. Epigenetic mechanisms such as DNA methylation (DNAm) could contribute.

Objective

To examine relationships between maternal glycaemia, insulinemic status and dietary glycaemic indices during pregnancy and an antenatal behavioral-lifestyle intervention with newborn DNAm.

Methods

We investigated 172 women from a randomized controlled trial of a lifestyle intervention in pregnant women with overweight and obesity. Fasting glucose and insulin concentrations and derived indices of insulin resistance (HOMA-IR), β-cell function (HOMA-%B) and insulin sensitivity (QUICKI) were determined at baseline (15) and 28 week's gestation. Dietary glycaemic load (GL) and index (GI) were

SUBMITTER: Lecorguille M 

PROVIDER: S-EPMC9759168 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature