Biodegradable external wrapping promotes favorable adaptation in an ovine vein graft model.

ABSTRACT: Vein grafts, the most commonly used conduits in multi-vessel coronary artery bypass grafting surgery, have high intermediate- and long-term failure rates. The abrupt and marked increase in hemodynamic loads on the vein graft is a known contributor to failure. Recent computational modeling suggests that veins can more successfully adapt to an increase in mechanical load if the rate of loading is gradual. Applying an external wrap or support at the time of surgery is one way to reduce the transmural load, and this approach has improved performance relative to an unsupported vein graft in several animal studies. Yet, a clinical trial in humans has shown benefits and drawbacks, and mechanisms by which an external wrap affects vein graft adaptation remain unknown. This study aims to elucidate s

SUBMITTER: Ramachandra AB 

PROVIDER: S-EPMC9759202 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature