The TNF-α-308G/A Gene Polymorphism and Serum TNF-α Levels in Women With Preeclampsia.

ABSTRACT: Objective: Worldwide, preeclampsia (PE) is a multifactorial disorder reported in 2-5% of pregnancies, which increases mortality during pregnancy. In general, 10-15% of maternal deaths are directly related to PE and eclampsia. One of the susceptibility genes for PE is tumor necrosis factor-α (TNF-α) expressed by most immune cells. TNF-α is a protein involved in various biological processes, including proliferation and apoptosis, as well as the expression of inflammatory genes. The goal of this study was to investigate the role of TNF-α single nucleotide polymorphism (SNP) -308G/A (rs1800629) and their relationship with TNF-α in PE patients. Materials and methods: The SNP was genotyped in 90 cases and 90 controls. Whole blood was collected from women with PE and normal pregnanc

SUBMITTER: Khodadadi A 

PROVIDER: S-EPMC9759434 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature