Programmable DNA biocomputing circuits for rapid and intelligent screening of SARS-CoV-2 variants.

ABSTRACT: The frequent emergence of SARS-CoV-2 variants increased viral transmissibility and reduced protection afforded by vaccines. The rapid, multichannel, and intelligent screening of variants is critical to minimizing community transmissions. DNA molecular logic gates have attracted wide attention in recent years due to the powerful information processing capabilities and molecular data biocomputing functions. In this work, some molecular switches (MSs) were connected with each other to implement arbitrary binary functions by emulating the threshold switching of MOS transistors and the decision tree model. Using specific sequences of different SARS-CoV-2 variants as inputs, the MSs net was used to build several molecular biocomputing circuits, including NOT, AND, OR, INHIBIT, XOR, half adder, h

SUBMITTER: Deng F 

PROVIDER: S-EPMC9759469 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature