Ontology highlight
ABSTRACT:
SUBMITTER: Sudol ASL
PROVIDER: S-EPMC9759587 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Sudol Abigail S L ASL Butler John J Ivory Dylan P DP Tews Ivo I Crispin Max M
Nature communications 20221217 1
Enzymatic cleavage of IgG antibodies is a common strategy used by pathogenic bacteria to ablate immune effector function. The Streptococcus pyogenes bacterium secretes the protease IdeS and the glycosidase EndoS, which specifically catalyse cleavage and deglycosylation of human IgG, respectively. IdeS has received clinical approval for kidney transplantation in hypersensitised individuals, while EndoS has found application in engineering antibody glycosylation. We present crystal structures of b ...[more]