Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study.

ABSTRACT:

Background

The prevalence of type 2 diabetes has dramatically increased in the past years. Increasing evidence supports that blood DNA methylation, the best studied epigenetic mark, is related to diabetes risk. Few prospective studies, however, are available. We studied the association of blood DNA methylation with diabetes in the Strong Heart Study. We used limma, Iterative Sure Independence Screening and Cox regression to study the association of blood DNA methylation with fasting glucose, HOMA-IR and incident type 2 diabetes among 1312 American Indians from the Strong Heart Study. DNA methylation was measured using Illumina's MethylationEPIC beadchip. We also assessed the biological relevance of our findings using bioinformatics analyses.

Results

Among the 358 differentia

SUBMITTER: Domingo-Relloso A 

PROVIDER: S-EPMC9759920 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature