Six potential biomarkers for bladder cancer: key proteins in cell-cycle division and apoptosis pathways.

ABSTRACT:

Background

The bladder cancer (BC) pathology is caused by both exogenous environmental and endogenous molecular factors. Several genes have been implicated, but the molecular pathogenesis of BC and its subtypes remains debatable. The bioinformatic analysis evaluates high numbers of proteins in a single study, increasing the opportunity to identify possible biomarkers for disorders.

Methods

The aim of this study is to identify biomarkers for the identification of BC using several bioinformatic analytical tools and methods. BC and normal samples were compared for each probeset with T test in GSE13507 and GSE37817 datasets, and statistical probesets were verified with GSE52519 and E-MTAB-1940 datasets. Differential gene expression, hierarchical clustering, gene ontology enrichm

SUBMITTER: Inal Gultekin G 

PROVIDER: S-EPMC9760318 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature