Ontology highlight
ABSTRACT:
SUBMITTER: Patel P
PROVIDER: S-EPMC9760367 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Patel Priya P Alghamdi Areej A Shaw Gary G Legge Christopher C Glover Maggie M Freeman Danielle D Hodgetts Harry H Wilson Erica E Howard Faith F Staniland Sarah S Kennerley Aneurin J AJ Wood Duncan D Moorehead Robert R Hadfield Charlotte C Rominiyi Ola O Griffin Jon J Collis Spencer J SJ Hyde Sam S Crossley Marcus M Paley Martyn M Muthana Munitta M
Nanotheranostics 20230101 1
Delivering therapies to deeply seated brain tumours (BT) is a major clinical challenge. Magnetic drug targeting (MDT) could overcome this by rapidly transporting magnetised drugs directly into BT. We have developed a magnetic device for application in murine BT models using an array of neodymium magnets with a combined strength of 0.7T. In a closed fluidic system, the magnetic device trapped magnetic nanoparticles (MNP) up to distances of 0.8cm. In mice, the magnetic device guided intravenously ...[more]