Development of a Personalised Device for Systemic Magnetic Drug Targeting to Brain Tumours.

ABSTRACT: Delivering therapies to deeply seated brain tumours (BT) is a major clinical challenge. Magnetic drug targeting (MDT) could overcome this by rapidly transporting magnetised drugs directly into BT. We have developed a magnetic device for application in murine BT models using an array of neodymium magnets with a combined strength of 0.7T. In a closed fluidic system, the magnetic device trapped magnetic nanoparticles (MNP) up to distances of 0.8cm. In mice, the magnetic device guided intravenously administered MNP (<50nm) from the circulation into the brain where they localised within mouse BT. Furthermore, MDT of magnetised Temozolomide (TMZ^mag+) significantly reduced tumour growth and extended mouse survival to 48 days compared to the other treatment groups. Using the same princi

SUBMITTER: Patel P 

PROVIDER: S-EPMC9760367 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature