Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients.

ABSTRACT: Cancer patients often suffer from cancer symptoms, treatment complications and concomitant diseases and are, therefore, often treated with several drugs in addition to anticancer drugs. Whether such drugs, here denoted as 'concomitant drugs', have anticancer effects or interact at the tumor cell level with the anticancer drugs is not very well known. The cytotoxic effects of nine concomitant drugs and their interactions with five anti-cancer drugs commonly used for the treatment of colorectal cancer were screened over broad ranges of drug concentrations in vitro in the human colon cancer cell line HCT116wt. Seven additional tyrosine kinase inhibitors were included to further evaluate key findings as were primary cultures of tumor cells from patients with colorectal cancer. Cytotoxic effect

SUBMITTER: Andersson CR 

PROVIDER: S-EPMC9760465 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature