Risk of Dental Discoloration and Enamel Dysplasia in Children Exposed to Tetracycline and Its Derivatives.

ABSTRACT:

Purpose

To examine the risk of dental abnormalities after exposure to tetracycline and its derivatives (TCs) in Korean children.

Materials and methods

Children aged 0-17 years with a claim for prescriptions of TCs between 2002 and 2015 were identified from the Sample Research Database 2.0 of the National Health Insurance Service. Children not exposed to TCs were selected as the control group by matching sex and age (1:4). Cumulative incidence rate and relative risk of dental abnormalities after TCs exposure were investigated.

Results

The 10-year cumulative incidence rate in the 0-12 years group was 3.1% [95% confidence interval (CI), 2.3-3.9]. The 10-year cumulative incidence rates were 7.0%, 1.9%, and 1.6% in the 0-7, 8-12, and 13-17 years age groups (95% CI: 4.7-9.3

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC9760895 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature