Mapping white matter structural and network alterations in betel quid-dependent chewers using high angular resolution diffusion imaging.

ABSTRACT:

Background

To evaluate brain white matter diffusion characteristics and anatomical network alterations in betel quid dependence (BQD) chewers using high angular resolution diffusion imaging (HARDI).

Methods

The current study recruited 53 BQD chewers and 37 healthy controls (HC) in two groups. We explored regional diffusion metrics alternations in the BQD group compared with the HC group using automated fiber quantification (AFQ). We further employed the white matter (WM) anatomical network of HARDI to explore connectivity alterations in BQD chewers using graph theory.

Results

BQD chewers presented significantly lower FA values in the left and right cingulum cingulate, the left and right thalamic radiation, and the right uncinate. The BQD has a significantly higher RD

SUBMITTER: Huang W 

PROVIDER: S-EPMC9760978 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature