Identification of the molecular mechanism and candidate markers for diabetic nephropathy.

ABSTRACT:

Background

Diabetic nephropathy (DN) is one of the most common complications in diabetic patients. New strategies are needed to delay the occurrence and development of this pathology.

Methods

Differentially expressed genes (DEGs) in glomeruli and renal tubules were identified using the GSE30122 dataset, and a co-expression network was constructed to identify the hub genes of modules. The biological function and signaling pathway of the module genes were also analyzed. In addition, the expression of 24 immune cells and the area under the receiver operating characteristic (ROC) curve (AUC) values of the hub genes were also calculated.

Results

A total of 1,778 DEGs were isolated from glomeruli and 1,996 DEGs were isolated from renal tubules. Nine modules and their hub ge

SUBMITTER: Chen C 

PROVIDER: S-EPMC9761143 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature