Bifidobacterium animalis subsp. lactis Bi-07 supports lactose digestion in vitro and in randomized, placebo- and lactase-controlled clinical trials.

ABSTRACT:

Background

Probiotics may alleviate lactose maldigestion.

Objectives

The objective was to select a probiotic with high lactase activity and compare it with lactase and placebo in clinical trials.

Methods

Bacterial cultures were screened for lactase activity in a model of the upper gastrointestinal (GI) tract. Bifidobacterium animalis subsp. lactis Bi-07 (Bi-07) counts were adjusted in subsequent experiments to correspond to 4500 Food Chemicals Codex (FCC) units of lactase, the amount in the European Food Safety Authority (EFSA)-approved health claim. Two crossover clinical trials, Booster Alpha and Booster Omega, were performed in participants with lactose intolerance, where 2 × 1012 CFUs Bi-07, 4662 FCC lactase, or placebo was consumed simultaneously with a lactose c

SUBMITTER: Rasinkangas P 

PROVIDER: S-EPMC9761758 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature