PD-1 and LAG-3-positive T cells are associated with clinical outcomes of relapsed/refractory multiple myeloma patients.

ABSTRACT:

Objective

To investigate the frequency of PD-1 and LAG-3-positive T cells in relapsed/refractory multiple myeloma (RRMM) patients and its clinical significance.

Methods

This prospective observational study enrolled a total of 71 RRMM patients, as well as 70 MM patients (non-refractory) and 70 healthy individuals during January 2018 to March 2021. The frequency of circulating CD4⁺ and CD8⁺ T cells expressing PD-1 and LAG-3 was analyzed using flow cytometry. Serum cytokines of IL-6, IL-17, CRP, TNF-α and TGF-β were evaluated by enzyme linked immunosorbent assay (ELISA).

Results

Significant higher 1-year mortality rate was found in RRMM patients compared with the MM patients. In both CD4⁺ and CD8⁺ T cells, the frequencies of PD

SUBMITTER: Chen M 

PROVIDER: S-EPMC9761990 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature