Maternal corticosteroids and depression during gestation and decreased fetal heart rate variability.

ABSTRACT:

Objective

Maternal depression during gestation is an adverse factor in fetal brain development that manifests in later childhood behavioral problems. Fetal heart rate variability (FHRV) mediated by parasympathetic input is a marker of gestational nervous system development. Biological mediators of adverse effects of maternal depression may involve the mother's corticosteroids; however, links between depression, corticosteroids, and early nervous system development remain inconclusive.

Methods

Heart rate was recorded in 23 fetuses by transabdominal Doppler at 28-33 weeks gestation. The SD of interbeat intervals over 20 min assessed FHRV. Maternal depression ratings and hair concentrations of cortisol and cortisone were assayed. An auditory sensory gating paradigm assessed new

SUBMITTER: Hunter SK 

PROVIDER: S-EPMC9762166 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature