A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects millions of people worldwide. AD pathogenesis is intricate. It primarily involves two main molecular players-amyloid-β (Aβ) and tau-which actually have an intrinsic trend to generate molecular assemblies that are toxic to neurons. Incomplete knowledge of the molecular mechanisms inducing the onset and sustaining the progression of the disease, as well as the lack of valid models to fully recapitulate the pathogenesis of human disease, have until now hampered the development of a successful therapy for AD. The overall experience with clinical trials with a number of potential drugs-including the recent outcomes of studies with monoclonal antibodies against Aβ-seems to indicate that Aβ-targeting is not effect

SUBMITTER: Catania M 

PROVIDER: S-EPMC9763104 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature