Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample.

ABSTRACT: Endophenotypes are heritable and quantifiable traits indexing genetic liability for a disorder. Here, we examined three potential endophenotypes, working memory function, response inhibition, and reaction time variability, for attention-deficit hyperactivity disorder (ADHD) measured as a dimensional latent trait in a large general population sample derived from the Adolescent Brain Cognitive Development^SM Study. The genetic risk for ADHD was estimated using polygenic risk scores (PRS) whereas ADHD traits were quantified as a dimensional continuum using Bartlett factor score estimates, derived from Attention Problems items from the Child Behaviour Checklist and Effortful Control items from the Early Adolescent Temperament Questionnaire-Revised. The three candidate cognitive endop

SUBMITTER: Moses M 

PROVIDER: S-EPMC9763105 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature