A circuit from lateral septum neurotensin neurons to tuberal nucleus controls hedonic feeding.

ABSTRACT: Feeding behavior is regulated by both the homeostatic needs of the body and hedonic values of the food. Easy access to palatable energy-dense foods and the consequent obesity epidemic stress the urgent need for a better understanding of neural circuits that regulate hedonic feeding. Here, we report that neurotensin-positive neurons in the lateral septum (LS^Nts) play a crucial role in regulating hedonic feeding. Silencing LS^Nts specifically promotes feeding of palatable food, whereas activation of LS^Nts suppresses overall feeding. LS^Nts neurons project to the tuberal nucleus (TU) via GABA signaling to regulate hedonic feeding, while the neurotensin signal from LS^Nts→the supramammillary nucleus (SUM) is sufficient to suppress overall fee

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9763109 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature