Rare copy number variation in posttraumatic stress disorder.

ABSTRACT: Posttraumatic stress disorder (PTSD) is a heritable (h² = 24-71%) psychiatric illness. Copy number variation (CNV) is a form of rare genetic variation that has been implicated in the etiology of psychiatric disorders, but no large-scale investigation of CNV in PTSD has been performed. We present an association study of CNV burden and PTSD symptoms in a sample of 114,383 participants (13,036 cases and 101,347 controls) of European ancestry. CNVs were called using two calling algorithms and intersected to a consensus set. Quality control was performed to remove strong outlier samples. CNVs were examined for association with PTSD within each cohort using linear or logistic regression analysis adjusted for population structure and CNV quality metrics, then inverse variance weighted

SUBMITTER: Maihofer AX 

PROVIDER: S-EPMC9763110 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature