Bioenergetic changes in response to sperm capacitation and two-way metabolic compensation in a new murine model.

ABSTRACT: The acquisition of fertilizing ability by mammalian spermatozoa, known as "capacitation," includes processes that depend on particular metabolic pathways. This has led to the hypothesis that ATP demands might differ between capacitated and non-capacitated cells. Mouse sperm can produce ATP via OXPHOS and aerobic glycolysis, an advantageous characteristic considering that these cells have to function in the complex and variable environment of the female reproductive tract. Nonetheless, despite evidence showing that both metabolic pathways play a role in events associated with mouse sperm capacitation, there is contradictory evidence regarding changes promoted by capacitation in this species. In addition, the vast majority of studies regarding murine sperm metabolism use Mus musculus laborat

SUBMITTER: Tourmente M 

PROVIDER: S-EPMC9763147 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature