Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study.

ABSTRACT:

Objective

Remote ischaemic conditioning (RIC) improves the outcome of experimental necrotising enterocolitis (NEC) by preserving intestinal microcirculation. The feasibility and safety of RIC in preterm infants with NEC are unknown. The study aimed to assess the feasibility and safety of RIC in preterm infants with suspected or confirmed NEC.

Design

Phase I non-randomised pilot study conducted in three steps: step A to determine the safe duration of limb ischaemia (up to 4 min); step B to assess the safety of 4 repeated cycles of ischaemia-reperfusion at the maximum tolerated duration of ischaemia determined in step A; step C to assess the safety of applying 4 cycles of ischaemia-reperfusion on two consecutive days.

Setting

Level III neonatal intensive care unit, The

SUBMITTER: Zozaya C 

PROVIDER: S-EPMC9763186 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature